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1

Floating gastroretentive drug delivery systems: Comparison of experimental and simulated dissolution profiles and floatation behavior

Eberle, Veronika A., Schoelkopf, Joachim, Gane, Patrick A.C., Alles, Rainer, Huwyler, Jörg, Puchkov, Maxim

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 1.66 MB

english, 2014

2

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

Wicki, Andreas, Witzigmann, Dominik, Balasubramanian, Vimalkumar, Huwyler, Jörg

Journal:

Journal of Controlled Release

Year:

2015

Language:

english

File:

PDF, 953 KB

english, 2015

3

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial

Speich, Benjamin, Ali, Said M, Ame, Shaali M, Bogoch, Isaac I, Alles, Rainer, Huwyler, Jörg, Albonico, Marco, Hattendorf, Jan, Utzinger, Jürg, Keiser, Jennifer

Journal:

The Lancet Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 291 KB

english, 2015

4

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Farzan, Maryam, Roth, Roger, Québatte, Gabriela, Schoelkopf, Joachim, Huwyler, Jörg, Puchkov, Maxim

Journal:

Year:

2019

File:

PDF, 25.39 MB

2019

5

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

Stefanie Bendels, Manfred Kansy, Björn Wagner, Jörg Huwyler

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 541 KB

english, 2008

6

A Binary Ant Colony Optimization Classifier for Molecular Activities

Hammann, Felix, Suenderhauf, Claudia, Huwyler, Jörg

Journal:

Journal of Chemical Information and Modeling

Year:

2011

Language:

english

File:

PDF, 3.10 MB

english, 2011

7

Development and validation of an enantioselective LC–MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots

Meister, Isabel, Leonidova, Anna, Kovač, Jana, Duthaler, Urs, Keiser, Jennifer, Huwyler, Jörg

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

8

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator

Folzer, Emilien, Khan, Tarik A., Schmidt, Roland, Finkler, Christof, Huwyler, Jörg, Mahler, Hanns-Christian, Koulov, Atanas V.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 342 KB

english, 2015

9

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo

Sieber, Sandro, Grossen, Philip, Detampel, Pascal, Siegfried, Salome, Witzigmann, Dominik, Huwyler, Jörg

Journal:

Journal of Controlled Release

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

10

Directing Nanoparticle Biodistribution Through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

Campbell, Frederick, Bos, Frank L., Sieber, Sandro, Arias-Alpizar, Gabriela, Koch, Bjørn E., Huwyler, Jörg, Kros, Alexander, Bussmann, Jeroen

Journal:

Year:

2018

Language:

english

File:

PDF, 54.69 MB

english, 2018

11

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients

Meister, Isabel, Kovac, Jana, Duthaler, Urs, Odermatt, Peter, Huwyler, Jörg, Vanobberghen, Fiona, Sayasone, Somphou, Keiser, Jennifer, Geary, Timothy G.

Journal:

PLoS Neglected Tropical Diseases

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

12

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach

Sedighi, Mahsa, Sieber, Sandro, Rahimi, Fereshteh, Shahbazi, Mohammad-Ali, Rezayan, Ali Hossein, Huwyler, Jörg, Witzigmann, Dominik

Journal:

Drug Delivery and Translational Research

Year:

2018

Language:

english

File:

PDF, 6.55 MB

english, 2018

13

Lipid-Based DNA Therapeutics – Hallmarks of Non-Viral Gene Delivery

Buck, Jonas, Grossen, Philip, Cullis, Pieter R, Huwyler, Jörg, Witzigmann, Dominik

Journal:

Year:

2019

Language:

english

File:

PDF, 1.14 MB

english, 2019

14

Impact of solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats

Beate Bittner, Roberto Carlos Bravo González, Isabelle Walter, Martin Kapps, Jörg Huwyler

Journal:

Biopharmaceutics & Drug Disposition

Year:

2003

Language:

english

File:

PDF, 113 KB

english, 2003

15

In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam

Roberto C. Bravo González, Jörg Huwyler, Franziska Boess, Isabelle Walter, Beate Bittner

Journal:

Biopharmaceutics & Drug Disposition

Year:

2004

Language:

english

File:

PDF, 289 KB

english, 2004

16

Targeting of the photocytotoxic compound AlPcS4 to hela cells by transferrin conjugated peg-liposomes

Antoon Gijsens, Annelies Derycke, Ludwig Missiaen, Dirk De Vos, Jörg Huwyler, Alex Eberle, Peter de Witte

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 2.63 MB

english, 2002

17

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma

Urs Duthaler, Jennifer Keiser, Jörg Huwyler

Journal:

Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 228 KB

english, 2011

18

In vitro assessment of the formation of ceftriaxone–calcium precipitates in human plasma

Hans-Rudolf Schmutz, Pascal Detampel, Theo Bühler, André Büttler, Benjamin Gygax, Jörg Huwyler

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 292 KB

english, 2011

19

Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chromatography

Jörg Huwyler, Stefan Rufer, Ernst Küsters, Jürgen Drewe

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 360 KB

english, 1995

20

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Thomas J. Woltering, Jürgen Wichmann, Erwin Goetschi, Geo Adam, James N.C. Kew, Frédéric Knoflach, Theresa M. Ballard, Jörg Huwyler, Vincent Mutel, Silvia Gatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

21

A potentiometric titration method for the crystallization of drug-like organic molecules

Lei Du-Cuny, Jörg Huwyler, Holger Fischer, Manfred Kansy

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 696 KB

english, 2007

22

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel, Jürgen Wichmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 183 KB

english, 2005

23

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Bernd Büttelmann, Jens-Uwe Peters, Simona Ceccarelli, Sabine Kolczewski, Eric Vieira, Eric P. Prinssen, Will Spooren, Franz Schuler, Jörg Huwyler, Richard H.P. Porter, Georg Jaeschke

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 170 KB

english, 2006

24

Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Simona M. Ceccarelli, Georg Jaeschke, Bernd Buettelmann, Jörg Huwyler, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Richard Porter, Will Spooren, Eric Vieira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 172 KB

english, 2007

25

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel, Jürgen Wichmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 273 KB

english, 2009

26

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Thomas J. Woltering, Jürgen Wichmann, Erwin Goetschi, Frédéric Knoflach, Theresa M. Ballard, Jörg Huwyler, Silvia Gatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.79 MB

english, 2010

27

Computational aqueous solubility prediction for drug-like compounds in congeneric series

Lei Du-Cuny, Jörg Huwyler, Michael Wiese, Manfred Kansy

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 893 KB

english, 2008

28

Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate

Carla Kirchhofer, Jennifer Keiser, Jörg Huwyler

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 331 KB

english, 2010

29

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Jennifer Keiser, Carla Kirchhofer, Manuel Haschke, Jörg Huwyler, Yuxiang Dong, Jonathan L. Vennerstrom, Kathleen Vanhoff, Ronald Kaminsky, Nick Malikides

Journal:

Veterinary Parasitology

Year:

2010

Language:

english

File:

PDF, 206 KB

english, 2010

30

High-performance liquid chromatographic method for an automated determination of local anaesthetics in human plasma

Jürgen Drewe, Stefan Rufer, Jörg Huwyler, Ernst Küsters

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1997

Language:

english

File:

PDF, 406 KB

english, 1997

31

Improved oral bioavailability of cyclosporin A in male Wistar rats: Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension

Roberto Carlos Bravo González, Jörg Huwyler, Isabelle Walter, Richard Mountfield, Beate Bittner

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

32

Examination of Blood-Brain Barrier Transferrin Receptor by Confocal Fluorescent Microscopy of Unfixed Isolated Rat Brain Capillaries

Jörg Huwyler, William M. Pardridge

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 551 KB

english, 1998

33

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

Theresa M. Ballard, Marie L. Woolley, Eric Prinssen, Jörg Huwyler, Richard Porter, Will Spooren

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

34

Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions

Michael Török, Jörg Huwyler, Heike Gutmann, Gert Fricker, Jürgen Drewe

Journal:

Experimental Brain Research

Year:

2003

Language:

english

File:

PDF, 327 KB

english, 2003

35

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

Birk Poller, Jürgen Drewe, Stephan Krähenbühl, Jörg Huwyler, Heike Gutmann

Journal:

Cellular and Molecular Neurobiology

Year:

2010

Language:

english

File:

PDF, 265 KB

english, 2010

36

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Georg Jaeschke, Richard Porter, Bernd Büttelmann, Simona M. Ceccarelli, Wolfgang Guba, Bernd Kuhn, Sabine Kolczewski, Jörg Huwyler, Vincent Mutel, Jens-Uwe Peters, Theresa Ballard, Eric Prinssen, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 206 KB

english, 2007

37

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

Birk Poller, Heike Gutmann, Stephan Krähenbühl, Babette Weksler, Ignacio Romero, Pierre-Olivier Couraud, Gerald Tuffin, Jürgen Drewe, Jörg Huwyler

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

38

Mechanisms of halothane toxicity: Novel insights

Josef Gut, Urs Christen, Jörg Huwyler

Journal:

Pharmacology & Therapeutics

Year:

1993

Language:

english

File:

PDF, 2.83 MB

english, 1993

39

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

Elizaveta Fasler-Kan, Claudia Suenderhauf, Natasha Barteneva, Birk Poller, Daniel Gygax, Jörg Huwyler

Journal:

Year:

2010

Language:

english

File:

PDF, 840 KB

english, 2010

40

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica

Urs Duthaler, Jörg Huwyler, Laura Rinaldi, Giuseppe Cringoli, Jennifer Keiser

Journal:

Veterinary Parasitology

Year:

2012

Language:

english

File:

PDF, 973 KB

english, 2012

41

HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833

Jürgen Drewe, Heike Gutmann, Gert Fricker, Michael Török, Christoph Beglinger, Jörg Huwyler

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 877 KB

english, 1999

42

Halothane metabolism : Impairment of hepatic ω-oxidation of leukotrienes in vivo and in vitro

Jörg HUWYLER, Gabriele JEDLITSCHKY, Dietrich KEPPLER, Josef GUT

Journal:

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

43

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane

Jörg HUWYLER, Daniel AESCHLIMANN, Urs CHRISTEN, Josef GUT

Journal:

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

44

Molecular mimicry of trifluoroacetylated human liver protein adducts by consitutive proteins and immunochemical evidence for its impairment in halothane hepatitis

Josef GUT, Urs CHRISTEN, Jörg HUWYLER, Maria BÜRGIN, J. Gerald KENNA

Journal:

Year:

1992

Language:

english

File:

PDF, 942 KB

english, 1992

45

Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro

Josef GUT, Jörg HUWYLER

Journal:

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

46

Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium

Jörg Huwyler, Jürgen Drewe, Caterina Klusemann, Gert Fricker

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.11 MB

english, 1996

47

Comparison of in Vitro P-Glycoprotein Screening Assays: Recommendations for Their Use in Drug Discovery

Schwab, Dietmar, Fischer, Holger, Tabatabaei, Ali, Poli, Sonia, Huwyler, Jörg

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

48

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells

Swen Seeland, Alexander Treiber, Mathias Hafner, Jörg Huwyler

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2011

Language:

english

File:

PDF, 567 KB

english, 2011

49

Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart

Jörg Huwyler, Josef Gut

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 684 KB

english, 1992

50

Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies

Carla Kirchhofer, Mireille Vargas, Jörg Huwyler, Jennifer Keiser

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2012

Language:

english

File:

PDF, 259 KB

english, 2012

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